Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case–control study
Identifieur interne : 001E32 ( Main/Exploration ); précédent : 001E31; suivant : 001E33Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case–control study
Auteurs : Pierre-Antoine Dugué [Australie] ; Maree T. Brinkman [Australie] ; Roger L. Milne [Australie] ; Ee Ming Wong [Australie] ; Liesel M. Fitzgerald [Australie] ; Julie K. Bassett [Australie] ; Jihoon E. Joo [Australie] ; Chol-Hee Jung [Australie] ; Enes Makalic [Australie] ; Daniel F. Schmidt [Australie] ; Daniel J. Park [Australie] ; Jessica Chung [Australie] ; Anthony D. Ta [Australie] ; Damien M. Bolton [Australie] ; Andrew Lonie [Australie] ; Anthony Longano [Australie] ; John L. Hopper [Australie] ; Gianluca Severi [Australie, France, Italie] ; Richard Saffery [Australie] ; Dallas R. English [Australie] ; Melissa C. Southey [Australie] ; Graham G. Giles [Australie]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2016.
Descripteurs français
- KwdFr :
- ADN (sang), Adulte, Adulte d'âge moyen, Carcinome transitionnel (anatomopathologie), Carcinome transitionnel (génétique), Carcinome transitionnel (sang), Carcinome transitionnel (épidémiologie), Facteurs de risque, Facteurs temps, Femelle, Humains, Ilots CpG, Incidence, Invasion tumorale, Mâle, Méthylation de l'ADN, Prélèvement sanguin, Risque, Régime alimentaire, Sujet âgé, Tabagisme (épidémiologie), Tumeurs urologiques (anatomopathologie), Tumeurs urologiques (génétique), Tumeurs urologiques (sang), Tumeurs urologiques (épidémiologie), Victoria (épidémiologie), Étude d'association pangénomique, Études cas-témoins, Études de suivi, Études prospectives.
- MESH :
- anatomopathologie : Carcinome transitionnel, Tumeurs urologiques.
- génétique : Carcinome transitionnel, Tumeurs urologiques.
- sang : ADN, Carcinome transitionnel, Tumeurs urologiques.
- épidémiologie : Carcinome transitionnel, Tabagisme, Tumeurs urologiques, Victoria.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Facteurs temps, Femelle, Humains, Ilots CpG, Incidence, Invasion tumorale, Mâle, Méthylation de l'ADN, Prélèvement sanguin, Risque, Régime alimentaire, Sujet âgé, Étude d'association pangénomique, Études cas-témoins, Études de suivi, Études prospectives.
English descriptors
- KwdEn :
- Adult, Aged, Blood Specimen Collection, Carcinoma, Transitional Cell (blood), Carcinoma, Transitional Cell (epidemiology), Carcinoma, Transitional Cell (genetics), Carcinoma, Transitional Cell (pathology), Case-Control Studies, CpG Islands, DNA (blood), DNA Methylation, Diet, Female, Follow-Up Studies, Genome-Wide Association Study, Humans, Incidence, Male, Middle Aged, Neoplasm Invasiveness, Prospective Studies, Risk, Risk Factors, Smoking (epidemiology), Time Factors, Urologic Neoplasms (blood), Urologic Neoplasms (epidemiology), Urologic Neoplasms (genetics), Urologic Neoplasms (pathology), Victoria (epidemiology).
- MESH :
- chemical , blood : DNA.
- blood : Carcinoma, Transitional Cell, Urologic Neoplasms.
- epidemiology : Carcinoma, Transitional Cell, Smoking, Urologic Neoplasms, Victoria.
- genetics : Carcinoma, Transitional Cell, Urologic Neoplasms.
- pathology : Carcinoma, Transitional Cell, Urologic Neoplasms.
- Adult, Aged, Blood Specimen Collection, Case-Control Studies, CpG Islands, DNA Methylation, Diet, Female, Follow-Up Studies, Genome-Wide Association Study, Humans, Incidence, Male, Middle Aged, Neoplasm Invasiveness, Prospective Studies, Risk, Risk Factors, Time Factors.
Abstract
Global DNA methylation has been reported to be associated with urothelial cell carcinoma (UCC) by studies using blood samples collected at diagnosis. Using the Illumina HumanMethylation450 assay, we derived genome-wide measures of blood DNA methylation and assessed them for their prospective association with UCC risk.
We used 439 case–control pairs from the Melbourne Collaborative Cohort Study matched on age, sex, country of birth, DNA sample type, and collection period. Conditional logistic regression was used to compute odds ratios (OR) of UCC risk per s.d. of each genome-wide measure of DNA methylation and 95% confidence intervals (CIs), adjusted for potential confounders. We also investigated associations by disease subtype, sex, smoking, and time since blood collection.
The risk of superficial UCC was decreased for individuals with higher levels of our genome-wide DNA methylation measure (OR=0.71, 95% CI: 0.54–0.94;
Higher levels of our genome-wide DNA methylation measure were associated with decreased risk of superficial UCC and intermediate levels were associated with reduced risk of invasive disease. These findings require replication by other prospective studies.
Url:
DOI: 10.1038/bjc.2016.237
PubMed: 27490804
PubMed Central: 5023776
Affiliations:
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Paris-Sud, UVSQ, CESP, INSERM</institution>, Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Gustave Roussy</institution>, Villejuif F-94805,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>HuGeF, Human Genetics Foundation</institution>, Torino 10126,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Paediatrics, University of Melbourne</institution>, Melbourne, VIC,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Cancer, Disease and Developmental Epigenetics Group, Cell Biology, Development and Disease Theme, Murdoch Childrens Research Institute, Royal Children's Hospital</institution>, Melbourne, VIC,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R" last="English">Dallas R. English</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, VIC 3004,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. 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Brinkman</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, VIC 3004,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, VIC 3004,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Ee Ming" sort="Wong, Ee Ming" uniqKey="Wong E" first="Ee Ming" last="Wong">Ee Ming Wong</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M" last="Fitzgerald">Liesel M. Fitzgerald</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, VIC 3004,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Menzies Institute for Medical Research, University of Tasmania</institution>, Hobart, TAS 7000,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K" last="Bassett">Julie K. Bassett</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, VIC 3004,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Joo, Jihoon E" sort="Joo, Jihoon E" uniqKey="Joo J" first="Jihoon E" last="Joo">Jihoon E. Joo</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jung, Chol Hee" sort="Jung, Chol Hee" uniqKey="Jung C" first="Chol-Hee" last="Jung">Chol-Hee Jung</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>VLSCI Life Sciences Computation Centre, University of Melbourne</institution>, Carlton, VIC 3053,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Jessica" sort="Chung, Jessica" uniqKey="Chung J" first="Jessica" last="Chung">Jessica Chung</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Menzies Institute for Medical Research, University of Tasmania</institution>, Hobart, TAS 7000,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ta, Anthony D" sort="Ta, Anthony D" uniqKey="Ta A" first="Anthony D" last="Ta">Anthony D. Ta</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Surgery, University of Melbourne</institution>, Melbourne, VIC 3004,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bolton, Damien M" sort="Bolton, Damien M" uniqKey="Bolton D" first="Damien M" last="Bolton">Damien M. Bolton</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Surgery, University of Melbourne</institution>, Melbourne, VIC 3004,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>VLSCI Life Sciences Computation Centre, University of Melbourne</institution>, Carlton, VIC 3053,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Longano, Anthony" sort="Longano, Anthony" uniqKey="Longano A" first="Anthony" last="Longano">Anthony Longano</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Anatomical Pathology, Monash Medical Centre</institution>, Clayton, VIC 3800,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, VIC 3004,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>, Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Gustave Roussy</institution>, Villejuif F-94805,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>HuGeF, Human Genetics Foundation</institution>, Torino 10126,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Paediatrics, University of Melbourne</institution>, Melbourne, VIC,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Cancer, Disease and Developmental Epigenetics Group, Cell Biology, Development and Disease Theme, Murdoch Childrens Research Institute, Royal Children's Hospital</institution>, Melbourne, VIC,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R" last="English">Dallas R. English</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, VIC 3004,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>, Melbourne, VIC 3004,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>, Parkville, VIC 3052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Blood Specimen Collection</term><term>Carcinoma, Transitional Cell (blood)</term><term>Carcinoma, Transitional Cell (epidemiology)</term><term>Carcinoma, Transitional Cell (genetics)</term><term>Carcinoma, Transitional Cell (pathology)</term><term>Case-Control Studies</term><term>CpG Islands</term><term>DNA (blood)</term><term>DNA Methylation</term><term>Diet</term><term>Female</term><term>Follow-Up Studies</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Invasiveness</term><term>Prospective Studies</term><term>Risk</term><term>Risk Factors</term><term>Smoking (epidemiology)</term><term>Time Factors</term><term>Urologic Neoplasms (blood)</term><term>Urologic Neoplasms (epidemiology)</term><term>Urologic Neoplasms (genetics)</term><term>Urologic Neoplasms (pathology)</term><term>Victoria (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN (sang)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Carcinome transitionnel (anatomopathologie)</term><term>Carcinome transitionnel (génétique)</term><term>Carcinome transitionnel (sang)</term><term>Carcinome transitionnel (épidémiologie)</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Ilots CpG</term><term>Incidence</term><term>Invasion tumorale</term><term>Mâle</term><term>Méthylation de l'ADN</term><term>Prélèvement sanguin</term><term>Risque</term><term>Régime alimentaire</term><term>Sujet âgé</term><term>Tabagisme (épidémiologie)</term><term>Tumeurs urologiques (anatomopathologie)</term><term>Tumeurs urologiques (génétique)</term><term>Tumeurs urologiques (sang)</term><term>Tumeurs urologiques (épidémiologie)</term><term>Victoria (épidémiologie)</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term><term>Études de suivi</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>DNA</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome transitionnel</term><term>Tumeurs urologiques</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Carcinoma, Transitional Cell</term><term>Urologic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Carcinoma, Transitional Cell</term><term>Smoking</term><term>Urologic Neoplasms</term><term>Victoria</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoma, Transitional Cell</term><term>Urologic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome transitionnel</term><term>Tumeurs urologiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Transitional Cell</term><term>Urologic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ADN</term><term>Carcinome transitionnel</term><term>Tumeurs urologiques</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Carcinome transitionnel</term><term>Tabagisme</term><term>Tumeurs urologiques</term><term>Victoria</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Blood Specimen Collection</term><term>Case-Control Studies</term><term>CpG Islands</term><term>DNA Methylation</term><term>Diet</term><term>Female</term><term>Follow-Up Studies</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Invasiveness</term><term>Prospective Studies</term><term>Risk</term><term>Risk Factors</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Ilots CpG</term><term>Incidence</term><term>Invasion tumorale</term><term>Mâle</term><term>Méthylation de l'ADN</term><term>Prélèvement sanguin</term><term>Risque</term><term>Régime alimentaire</term><term>Sujet âgé</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term><term>Études de suivi</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Global DNA methylation has been reported to be associated with urothelial cell carcinoma (UCC) by studies using blood samples collected at diagnosis. Using the Illumina HumanMethylation450 assay, we derived genome-wide measures of blood DNA methylation and assessed them for their prospective association with UCC risk.</p></sec><sec><title>Methods:</title><p>We used 439 case–control pairs from the Melbourne Collaborative Cohort Study matched on age, sex, country of birth, DNA sample type, and collection period. Conditional logistic regression was used to compute odds ratios (OR) of UCC risk per s.d. of each genome-wide measure of DNA methylation and 95% confidence intervals (CIs), adjusted for potential confounders. We also investigated associations by disease subtype, sex, smoking, and time since blood collection.</p></sec><sec><title>Results:</title><p>The risk of superficial UCC was decreased for individuals with higher levels of our genome-wide DNA methylation measure (OR=0.71, 95% CI: 0.54–0.94; <italic>P</italic>=0.02). This association was particularly strong for current smokers at sample collection (OR=0.47, 95% CI: 0.27–0.83). Intermediate levels of our genome-wide measure were associated with decreased risk of invasive UCC. Some variation was observed between UCC subtypes and the location and regulatory function of the CpGs included in the genome-wide measures of methylation.</p></sec><sec><title>Conclusions:</title><p>Higher levels of our genome-wide DNA methylation measure were associated with decreased risk of superficial UCC and intermediate levels were associated with reduced risk of invasive disease. These findings require replication by other prospective studies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Dugue, Pierre Antoine" sort="Dugue, Pierre Antoine" uniqKey="Dugue P" first="Pierre-Antoine" last="Dugué">Pierre-Antoine Dugué</name></noRegion><name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K" last="Bassett">Julie K. Bassett</name><name sortKey="Bolton, Damien M" sort="Bolton, Damien M" uniqKey="Bolton D" first="Damien M" last="Bolton">Damien M. Bolton</name><name sortKey="Brinkman, Maree T" sort="Brinkman, Maree T" uniqKey="Brinkman M" first="Maree T" last="Brinkman">Maree T. Brinkman</name><name sortKey="Chung, Jessica" sort="Chung, Jessica" uniqKey="Chung J" first="Jessica" last="Chung">Jessica Chung</name><name sortKey="Dugue, Pierre Antoine" sort="Dugue, Pierre Antoine" uniqKey="Dugue P" first="Pierre-Antoine" last="Dugué">Pierre-Antoine Dugué</name><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R" last="English">Dallas R. English</name><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R" last="English">Dallas R. English</name><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M" last="Fitzgerald">Liesel M. Fitzgerald</name><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M" last="Fitzgerald">Liesel M. Fitzgerald</name><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><name sortKey="Joo, Jihoon E" sort="Joo, Jihoon E" uniqKey="Joo J" first="Jihoon E" last="Joo">Jihoon E. Joo</name><name sortKey="Jung, Chol Hee" sort="Jung, Chol Hee" uniqKey="Jung C" first="Chol-Hee" last="Jung">Chol-Hee Jung</name><name sortKey="Longano, Anthony" sort="Longano, Anthony" uniqKey="Longano A" first="Anthony" last="Longano">Anthony Longano</name><name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><name sortKey="Ta, Anthony D" sort="Ta, Anthony D" uniqKey="Ta A" first="Anthony D" last="Ta">Anthony D. Ta</name><name sortKey="Wong, Ee Ming" sort="Wong, Ee Ming" uniqKey="Wong E" first="Ee Ming" last="Wong">Ee Ming Wong</name></country><country name="France"><noRegion><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></noRegion><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></country><country name="Italie"><noRegion><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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